![]() Allergic rhinitisĪlthough most patients experience mango allergy after ingestion of the fruit, mango tree pollen was shown to be a sensitizing agent in 16% of patients with allergic rhinitis (12). It was suspected that the symptoms may be due to cross-reactivity with mugwort antigens (11). ![]() Testing of specific IgE in a 30-year old woman with history of seasonal rhinitis showed that this patient is multi-sensitized to a number of plant allergens however, the only severe anaphylactic reaction experienced until then was following mango ingestion. Approximately 10% of patients experienced severe reactions, 15% had mild reactions and the remaining presented with moderately severe reactions (6). In a study of 250 patients referred to hospital with fruit-induced anaphylaxis, 9.2% of cases were caused by mango. Anaphylactic shock may present within few minutes of mango ingestion (8). Patients may present with a combination of the following: erythema and urticaria, angioedema of the face or extremities, rhinorrhea and rhino-conjunctivitis, dyspnea/respiratory distress, cough, gastrointestinal symptoms. This can be localized or show systemic symptoms, including anaphylaxis. Immediate hypersensitivity is a common clinical presentation of mango allergy. Taxonomic ree of mango Mangifera indica (1) The fruit is commonly consumed raw or preserved in the form of juice, canned slices and chutneys (3). The mango plant and fruit are versatile from stem bark extracts and mangiferin as medicinal compounds (2), to food. ![]() The tree produces large inflorescences (up to 30 cm long), branched and heavily flowered (300–6000 flowers) the flowers colors vary depending on cultivar (1). The mango tree is a large evergreen plant, reaching upwards of 40 m the leaves have variable morphology, usually elliptic to lanceolate, leathery with visible nerves. The flesh varies in color and flavor a tough, fibrous seed is present within. The fruit is edible, variable in shape and size (up to and over 30 cm long) the skin is thick and can be variably colored, with green, red and yellow areas. Due to the many cultivars, phenotype of both tree and fruit varies greatly. IgE-inhibition and ELISA inhibition experiments were performed to analyze mango profilin cross-reactivity with profilins from birch pollen and high cross-reactivities have been found.Mango ( Mangifera indica) is the fruit of the mango tree, which can be found worldwide. IgE reactivity of recombinant mango profilin was investigated by immunoblot and 8 of 18 mango-allergic patients tested presented specific IgE-antibodies to recombinant mango profilin. Expression of the recombinant mango profilin was carried out in Escherichia coli BL21(DE3) using vector PET28a and the purification of the recombinant protein was performed via affinity chromatography with Ni+ coupled to sepharose. The deduced amino acid sequence of the corresponding protein show high identity with other allergenic profilins. Each mango profilin cDNA includes an open reading frame coding for 131 amino acids. In this study, two isoforms of mango fruits profilin were amplified by RT-PCR and 3'RACE from total RNA. Profilin has been assumed partly responsible for the cross-reactivity between mango fruit and other allergens but has not been finally clarified. Mango can cause severe anaphylactic reactions.
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